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NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (NDUFV3)
- Target
- NDUFV3
- Molecular classification
- Enzyme (accessory subunit), Mitochondrial respiratory chain protein, Oxidoreductase complex component
01
Overview
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (NDUFV3), is an accessory protein subunit of the large multi-subunit enzyme complex known as NADH:ubiquinone oxidoreductase or Complex I. This enzyme is located on the inner membrane of mitochondria and plays a critical role in cellular energy production by transferring electrons from NADH to ubiquinone during oxidative phosphorylation. NDUFV3 itself is not believed to be directly involved in catalysis but may serve structural or regulatory functions within the complex and may be one of the last subunits assembled into mature Complex I. It has also been identified as a renal carcinoma-associated antigen (NY‑REN‑4). Mutations or dysfunctions affecting components of Complex I can contribute to various human diseases including some cancers and inherited metabolic disorders.
- Other names
- Complex I-9kDCI-9kDNADH-ubiquinone oxidoreductase 9 kDa subunitRenal carcinoma antigen NY-REN-4
02
Mechanism of action
Acts as a cofactor in electron transfer from NADH to ubiquinone within Complex I of the mitochondrial respiratory chain
03
Biological functions
Electron transport in the mitochondrial respiratory chain (Complex I)Aerobic respiration / mitochondrial ATP synthesis coupled electron transport
04
Disease associations
Cancer (notably as renal carcinoma antigen NY‑REN‑4)
05
Safety considerations
No notable safety concerns or therapeutic challenges are specifically attributed to this accessory subunit. However, dysfunction of Complex I is broadly associated with mitochondrial diseases and metabolic disorders.
06
Interacting drugs
Ubidecarenone (coenzyme Q10; approved, investigational, nutraceutical)
07
Biomarkers
No specific biomarkers for patient selection or efficacy monitoring are directly listed for this subunit. However, its alias as "renal carcinoma antigen NY‑REN‑4" suggests potential use in cancer biomarker panels.
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